Fig. 1
From: Targeting epigenetic features in clear cell sarcomas based on patient-derived cell lines
Patient history. Magnet resonance of the left knee with a solid contrast enhancing lesion 6 × 5 × 3 cm on the anteromedial circumference of the knee joint with intra and extra-articular infiltration (A). Resection specimen with a multinodular gray soft tissue on the anteromedial aspect of the knee joint with articular infiltration (B). HE with an overview of tumor tissue located in the soft tissues. Regular skin, dermis and subcutaneous fat (C). Solid sheets of a monotonous proliferation of epithelioid tumor cells with prominent nucleoli and eosinophilic to clear cytoplasm (inset) (D). Nests, bundles and fascicle of tumor cells separated by dense fibrous stroma. Focal wreath-like multinucleated giant cells (inset) (E). Strong nuclear expression of SOX10 in all tumor cells (F). Nuclear and cytoplasmic expression of S100 in tumor cells (G). Strong cytoplasmic expression of HMB45 (H)