Fig. 6

BI 113823 treatment reduced human peripheral blood monocyte and neutrophil activation, migration and cytokine release. A TNF-α-induced migration in monocytes. B LPS-induced TNF-ɑ secretion in monocytes. C LPS-induced CD11/CD18 integrin’s expression FACS dot plots in monocytes. D TNF-α-induced neutrophils migration. E LPS-induced MPO activity in neutrophils. F LPS-induced CD11/CD18 integrin’s expression FACS dot plots in neutrophils. Values are mean ± SEM, n = 3–4. *p < 0.05; **p < 0.01; ***p < 0.001. p values indicated in panels, ns. not significant and Significant as *p < 0.05; **p < 0.01; ***p < 0.001. One-way ANOVA and Tukey’s multiple comparison test (A, B, D, E) were performed