Items | CN | EMCI | LMCI | AD | P values |
---|---|---|---|---|---|
(n = 51) | (n = 26) | (n = 26) | (n = 21) | ||
Age (years) | 74.08 ± 5.79 | 70.04 ± 6.87 | 70.81 ± 7.14 | 71.81 ± 7.77 | 0.051 |
Gender (F/M) | 30/21 | 14/12 | 11/15 | 9/12 | 0.447* |
Education (years) | 16.31 ± 2.59 | 15.27 ± 2.51 | 16.31 ± 2.51 | 15.14 ± 2.76 | 0.157 |
Multiple protective genes | |||||
CLU T status (TC + TT/CC) | 38/13 | 17/9 | 18/8 | 13/8 | 0.710* |
LDLR A status (AG + AA/GG) | 38/13 | 16/10 | 15/11 | 11/10 | 0.240* |
LRP1 T status (TC + TT/CC) | 15/36 | 8/18 | 5/21 | 10/11 | 0.214* |
PICALM A status (AG + AA/GG) | 27/24 | 15/11 | 16/10 | 11/10 | 0.884* |
Multiple risk genes | |||||
APOE ε4 status (+ / −) | 15/36 | 14/12 | 12/14 | 15/6 | 0.008* |
SORL1 G status (TG + GG/TT) | 19/32 | 12/14 | 12/14 | 6/15 | 0.548* |
CETP A status (AG + AA/GG) | 46/5 | 24/2 | 23/3 | 19/2 | 0.974* |
ABCA1 G status (AG + GG/AA) | 45/6 | 25/1 | 21/5 | 19/2 | 0.369* |
BIN1 C status (TC + CC/TT) | 27/24 | 17/9 | 15/11 | 11/10 | 0.739* |
Cerebrospinal fluid biomarkers | |||||
Aβ (pg/ml) | 192.79 ± 50.17bc | 183.61 ± 50.66d | 168.77 ± 50.80 | 140.40 ± 43.59 | 0.001 |
Tau (pg/ml) | 68.53 ± 34.14c | 79.32 ± 51.89d | 86.01 ± 52.19e | 129.29 ± 61.42 | < 0.001 |
pTau (pg/ml) | 34.18 ± 16.58bc | 39.60 ± 24.73d | 48.42 ± 33.50 | 55.23 ± 26.13 | 0.005 |
Global cognitive performance | |||||
MMSE | 28.84 ± 1.16abc | 27.92 ± 2.13d | 27.73 ± 1.54e | 22.67 ± 2.50 | < 0.001 |
ADAS-Cog | 10.76 ± 6.53abc | 14.19 ± 6.58d | 16.96 ± 5.32e | 35.81 ± 8.99 | < 0.001 |