Fig. 2

Mendelian Randomization (MR) analyses between SCZ and T2DM/T2DM-related trait of diastolic blood pressure. (A) The dual directional causal effect between SCZ and T2DM in different population with four methods, i.e. GSMR in blue, IVW in red, ML in yellow, WMe in purple. (B) Relationship of 45 instrumental variants’ effects on SCZ and those on DBP (diastolic blood pressure), each dot represents an instrumental variant, its 95% CIs for the estimated effect on SCZ and DBP denote horizontal and vertical lines, respectively, and the lines represent the causal effects of SCZ on DBP in the EUR population with four methods. (C) Sensitive analysis of each instrumental variant’s influence on the estimated causal effects of SCZ on DBP using the IVW method