Fig. 1From: 3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumorUptake mechanism of thymidine and [18F]FLT. Like thymidine, FLT is transported across cell membranes by nucleotide transporters. After uptake, [18F]FLT is phosphorylated by TK 1 and trapped intracellularly. Incorporation into DNA is limitedBack to article page