Fig. 6

Asprosin ameliorates plasma lipid profile and enhances RCT. A–D Circulating levels of TC, LDL-C, HDL-C and TG were measured by the enzymatic methods (n = 10 mice per group). E J774 macrophages loaded with ac-LDL and [³H]-cholesterol were injected into apo E^−/− mice. The radioactivity of [³H]-cholesterol in the plasma, liver and feces was determined by a liquid scintillation counter (n = 5 mice per group). F ELISA was used to detect plasma PCSK9 levels (n = 10 mice per group). Data are given as the mean ± SD. *P < 0.05, ***P < 0.001. NS indicates not significant