Fig. 8
![Fig. 8](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-022-03398-4/MediaObjects/12967_2022_3398_Fig8_HTML.png)
Overexpression of ISG15 promote migration and invasion ability of PCa cells. A, B Relative mRNA expression of ISG15 in PC-3 and 22RV-1 transfected with plasmids ISG15, NC, sh-ISG15, and sh-NC. C Overexpression of ISG15 promoted migration of PC-3 and 22RV-1. D Overexpression and knockdown of ISG15 promoted and inhibited, respectively, invasion ability of PC-3 and 22RV-1. **P < 0.01, ***P < 0.001,****P < 0.0001