Fig. 7
![Fig. 7](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-022-03398-4/MediaObjects/12967_2022_3398_Fig7_HTML.png)
Expression of ISG15 and ZFP36 is increased and decreased in PCa respectively and is correlated with hypoxia. A The expression of ISG15 and ZFP36 increased and decreased respectively in PCa than in paracancerous tissues. B, C The expression of ISG15 and ZFP36 were significantly higher and lower respectively in PC-3, 22RV-1, LNCaP than in RWPE-1 at transcription level and protein level. D–K The expression level of ISG15 and ZFP36 in PC-3,22RV-1 and LNCaP was increased and decreased by the hypoxia at transcription level and protein level. **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. RWPE-1 and 0 h