Table 2 Patient demographic, clinical, and pathologic factors associated with PDX engraftment
Variable | n (%) | P value | |
|---|---|---|---|
Engrafted (n = 23) | Not engrafted (n = 116) | ||
Gender | |||
 Male | 19 (83) | 72 (62) | NS |
 Female | 4 (17) | 44 (38) | |
Race/ethnicity | |||
 Non-Hispanic White | 3 (13) | 27 (23) | < 0.05 |
 Black/African American | 10 (43) | 16 (14) | |
 Hispanic | 9 (39) | 68 (59) | |
 Asian | 1 (4) | 4 (3) | |
 American Indian | 0 (0) | 1 (1) | |
Presenting stage | |||
 Local | 0 (0) | 2 (2) | NS |
 Locally advanced | 13 (57) | 65 (56) | |
 Metastatic | 10 (43) | 49 (42) | |
Lauren classification | |||
 Intestinal | 14 (61) | 33 (35) | < 0.01 |
 Diffuse | 3 (13) | 51 (54) | |
 Mixed | 6 (26) | 11 (12) | |
 Unknown | 0 | 21 | |
Differentiation | |||
 Well | 0 (0) | 1 (1) | NS |
 Moderate | 7 (30) | 24 (22) | |
 Poor | 16 (70) | 86 (77) | |
 Unknown | 0 | 5 | |
H. pylori infection | |||
 Negative | 15 (79) | 67 (72) | NS |
 Positive | 4 (21) | 26 (28) | |
 Unknown | 4 | 23 | |
HER2 status | |||
 0–1+ or 2+ NAmp | 12 (75) | 60 (78) | NS |
 3+ or 2+ Amp | 4 (25) | 17 (22) | |
 Unknown | 7 | 39 | |
Tissue sourcea | |||
 EGD biopsy | 9 (39) | 96 (54) | NS |
 Resection | 8 (35) | 56 (32) | |
 Metastasis biopsy | 6 (26) | 25 (14) | |