Fig. 4
![Fig. 4](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-022-03286-x/MediaObjects/12967_2022_3286_Fig4_HTML.png)
RUNX3 promotes the expression of circDYRK1A and inhibits the progression of GC. A The expression of RUNX3 in microarray dataset GSE49051. B The expression of RUNX3 in GC tissues and adjacent normal tissues detected by RT-qPCR (n = 50). C RUNX3 expression in GC tissues and adjacent normal tissues measured by immunohistochemistry. D Pearson correlation analysis of the correlation between RUNX3 expression and circDYRK1A expression in GC tissues. E The enrichment of RUNX3 in circDYRK1A promoter region detected by ChIP assay. F The effect of RUNX3 on circDYRK1A promoter activity. G Expression of RUNX3 and circDYRK1A in AGS and HGC-27 cells measured by dual luciferase reporter assay. H Tumor size (left panel), growth curve (middle panel) and weight (right panel) in each group of mice detected (n = 6). I The apoptosis of tumor cells detected by TUNEL staining. Cell nuclei were stained in blue by hematoxylin, and yellow–brown cells are positive cells. J The expression of GLS and GDH (n = 6) measured by immunohistochemistry. The cell experiment was repeated three times. * p < 0.05