Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry

Table 3 Association analyses between PC status in persons with IBD and PRS estimated based on the IBD GWAS

	P-value threshold	Log OR	SE	P-value	R^2a
PC^b ~ PRS	5 × 10^–2	0.07	0.13	6.17E−01	0.001
	5 × 10^–3	0.65	0.15	1.86E−05***	0.065
	5 × 10^–4	0.61	0.15	3.64E−05***	0.059
PC ~ PRS + sex + age + marital status + disease subtypes	5 × 10^–2	0.06	0.14	6.41E−01	0.023
	5 × 10^–3	0.69	0.16	1.46E−05***	0.090
	5 × 10^–4	0.67	0.15	1.50E−05***	0.089

ISSN: 1479-5876