Table 2 Comparison of clinicopathological features between fusion-positive MLH1 hypermethylated colorectal cancers, and fusion-negative MLH1 hypermethylated colorectal cancers
|  | MLH1me+ with fusion (n = 22) | MLH1me+ without fusion (n = 69) | P# |
|---|---|---|---|
Age, median, years | 72 | 62 | 0.013 |
Gender, n(%) | |||
 Female | 13 (59) | 37 (54) | 0.806 |
 Male | 9 (41) | 32 (46) |  |
Tumor location, n(%) | |||
 Hepatic flexure | 13 (59) | 8 (12) |  < 0.001 |
 Other sites of large intestine | 9 (41) | 61 (78) |  |
  Ileocecum | 1 (5) | 20 (29) |  |
  Ascending colon | 5 (23) | 16 (23) |  |
  Transverse colon | 1 (5) | 6 (9) |  |
  Splenic flexure | 1 (5) | 2 (3) |  |
  Descending colon | 1 (5) | 5 (7) |  |
  Rectosigmoid | 0 | 12 (17) |  |
AJCC stage, n(%) | |||
 I | 0 (0) | 4 (5) | 0.925 |
 II | 15 (68) | 42 (61) |  |
 III | 7 (32) | 20 (29) |  |
 IV | 0 (0) | 2 (3) |  |
Presence of poor differentiated area, n(%) | |||
 Yes | 13 (59) | 18 (26) | 0.009 |
 No | 9 (41) | 51 (74) |  |
Mucinous differentiation, n(%) | |||
 Yes | 9 (41) | 25 (36) | 0.801 |
 No | 13 (59) | 44 (64) |  |
Lymphovascular invasion, n(%) | |||
 Yes | 10 (45) | 23 (33) | 0.445 |
 No | 12 (55) | 46 (67) |  |
Perineural invasion, n(%) | |||
 Yes | 3 (14) | 5 (7) |  |
 No | 19 (86) | 64 (93) |  |