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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA

Fig. 6

FBXO43 knockdown inhibited the proliferation and invasion of breast cancer cells by suppressing PCNA. A Co-IP analysis showed that ACLY, PCNA and VCP interacted with FBXO43. B HCS assay. C MTT assay. D Transwell migration assay (without ECM). E Cell cycle analysis. All experiments were performed at least three times. ECM, extracellular matrix. NC: negative control. KD-1 + NC: FBXO43 knockdown + negative control. KD-1 + ACLY: FBXO43 knockdown + ACLY overexpression. NC + PCNA: negative control + PCNA overexpression. KD-1 + PCNA: FBXO43 knockdown + PCNA overexpression. KD-1 + VCP: FBXO43 knockdown + VCP overexpression. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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