Fig. 2
From: Extrachromosomal circular DNA: a new potential role in cancer progression
Advanced eccDNA structure research methods. Five research methods can be used to study the advanced structure of eccDNA. A Circle-Sequencing (Circle-Seq). B Chromatin Immunoprecipitation Sequencing (ChIP-seq). C Circular chromosome conformation capture combined with high-throughput sequencing (4C-seq). D Proximity ligation-assisted ChIP-seq (PLAC-seq). E Assay for Targeting Accessible Chromatin with high-throughput sequencing (ATAC-seq)