Fig. 7
The distribution and clinical significance of TIME index (TI). The TI distribution of three TIME phenotypes in the TCGA cohort (a) and NCI cohort (b). c Alluvial diagram showing the changes of TI and the three TIME phenotypes. Kaplan–Meier curves for OS of HCC patients in the TCGA cohort (d) and NCI cohort (e). f The TI distribution in 33 cancer types. G Kaplan–Meier curves for OS of pancancer patients. h The univariate Cox’s regression result of TI in 33 cancer types. i The accuracy of TI and 11 other biomarkers in predicting immunotherapy, each cell represents the corresponding AUC value of one biomarker in one cohort. j The mean AUC of TI and 11 other biomarkers. For the boxplot, the asterisks represented the statistical p value (nsP > 0.05, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001)