Fig. 6

Methylation modification and regulation of the TIME phenotypes. a The distribution of global methylation level in three TIME phenotypes. Correlation of GML with CD8 T cells (b) and proliferation score (c). d The epigenetically silenced genes (ESGs) in three TIME phenotypes. Correlation of global methylation level (GML) with CD8 T cells and proliferation score. e The number of ESGs in three TIME phenotypes. f Differences in CD8 T cells and proliferation scores between FOXD4 methylated and FOXD4 unmethylated groups. g Differences in CD8 T cells and proliferation scores between L1TD1 methylated and L1TD1 unmethylated groups. h Differences in CD8 T cells and proliferation scores between PARP6 methylated and PARP6 unmethylated groups. For the boxplot, the asterisks represented the statistical p value (^nsP > 0.05, *P < 0.05, **P < 0.01, *** P < 0.001, **** P < 0.0001)