Fig. 7From: Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humansA snapshot of serum metabolites in the setting of familial hypercholesterolemia (discovery cohort). Human metabolomic signatures related to atherogenic dyslipidaemia closely reflect the pattern already identified in ApoE−/−/LDLR−/− mice. The top (a) row depicts serum concentration of substrates for NOSs (L-Arg, H-Arg) and Arg precursors (L-Cit, L-Orn), the middle rows -methylated Arg derivatives (NMMA, SDMA, ADMA) and L-Arg/ADMA ratio (b), and L-Met, Hcy (c), respectively and d refers to other altered metabolites determined in FH cases (n = 20) vs. healthy subjects (n = 20). Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. FH + S – FH patients on statinsBack to article page