Fig. 5

Effect of pro-atherogenic diets (Western and low-carbohydrate, high-protein (LCHP) diets) on plasma AA (amino acid-related) metabolome in ApoE^−/−/LDLR^−/− mice. Plasma concentration of substrates for NOSs (L-Arg, H-Arg) and Arg precursors (L-Cit, L-Orn) (a), methylated Arg derivatives (NMMA, SDMA, ADMA) as well as L-Arg/ADMA ratio (b), L-Met, Hcy (c) and other metabolites related to atherosclerosis progression (d) in 6-month-old ApoE^−/−/LDLR^−/− mice fed for 2 months: Control-AIN-93G (n = 6), WD (n = 5) or LCHP (n = 5) diet, respectively. Data represent mean ± SEM. *, **, and *** indicate P < 0.05, P < 0.01, P < 0.001, respectively