Fig. 5

Interaction between CEACAM1 and PI3K. a Protein levels of CEACAM1 in HBE cells pretreated with GDC0941 (GDC), BEZ235 (BEZ), GSK690693 (GSK), LY294002 (LY), CAL101 (CAL), and SHBM1009 (SHBM) 24 h after stimulation with IFN-γ for 24 h, as compared with control group with vehicle (CON). *, **, ***p-values less than 0.05, 0.01 and 0.005, as compared to HBE control, or ^{+, ++, +++}p-values less than 0.05, 0.01 and 0.005, as compared to IFN-γ with vehicle, respectively. b Levels of phosphorylated Akt protein (p-AKT) in cell^CEACAM1− or cell^CEACAM1+ treated with vehicle (control) or with IFN-γ at 10 ng/ml for 0 and 10 min. *p-values less than 0.05, as compared to control, ⁺p-values less than 0.05, as compared to 0 min group, respectively