Fig. 6
![Fig. 6](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12967-019-1857-8/MediaObjects/12967_2019_1857_Fig6_HTML.png)
FNDC5 overexpression (OE) attenuated cardiac hypertrophy, inflammation and oxidative stress in HFD-fed mice. a, b Serum and heart/muscle FNDC5 levels after lentiviral vector-mediated FNDC5 overexpression. c Cardiomyocyte area in heart determined by H&E staining. d, e mRNA levels of the cardiac hypertrophy markers (Nppa, Nppb and Myh7) and inflammation markers (Tnf-α, Il1b and Il6). f SOD activity and MDA level in heart. g NOX2, NOX4 level and NFκB inactivation in heart. h Phosphorylation levels of p38 and ERK in heart. Values are mean ± SEM. *P < 0.05 vs. vector. n = 6