Fig. 4

KA attenuated IR induced apoptosis. a–d Western blot analysis and histograms of apoptosis markers: Bcl-2, BAX and caspase3. After IR surgery, the apoptosis related factors BAX and Caspase 3 increased. KA reduced the expressions of BAX and Caspase 3, without improved the anti-apoptotic factor Bcl-2. However, the ratio of Bcl-2/BAX increased in IR + KA group, meaning a anti-apoptotic effect of KA on IR. Data were presented as mean ± SD. *p < 0.05, **p < 0.01 (unpaired nonparametric t-test); n = 3–5/group