Fig. 2

Prognostic value of PON1 in clinical applications. a Validation of PON1 expression differences in tumor tissues and adjacent non-tumor tissues by analyzing multicenter data sources that included 1432 samples. PON1 was downregulated in HCC tissues. b Comparison of the diagnostic ability of PON1, MKI67, and AFP via ROC curves. The diagnostic accuracy of PON1 (0.8119) was higher than that of AFP (0.6857) and lower than that of MKI67 (0.9515). c–f Density plot exhibiting the relationship between PON1 expression and clinicopathologic characteristics, including AJCC tumor stage, tumor T stage, tumor differentiation, and vascular invasion. The trend in the peaks indicated that low tumor expression was likely to be classified as a poor prognosis, including stage III, G4, macro vascular invasion, and T4. g Disease-free survival analysis of patients with low PON1 expression and high PON1 expression in the TCGA dataset (P-value = 0.013). h OS analysis of patients with low PON1 expression and high PON1 expression in TCGA dataset (P = 0.0014)