Distinct patterns and prognostic values of tumor-infiltrating macrophages in hepatocellular carcinoma and gastric cancer

Table 3 Association of Mφ with patients’ clinical characteristics

Characteristics	CD204⁺ Mφs^a		P ^b	CD169⁺ Mφs^a		P ^b
Characteristics	Low	High	P ^b	Low	High	P ^b
HCC patients
Gender (male/female)	73/19	81/10	0.104	75/19	81/10	0.105
HBV infection (no/yes)	7/85	11/80	0.333	8/86	11/83	0.629
Alpha-fetoprotein, ng/mL (≤25/>25)	42/50	30/61	0.096	36/58	38/56	0.881
Child–Pugh class (A/B)	85/7	85/6	1.000	89/5	86/8	0.567
Tumor number (single/multiple)	78/14	61/30	0.006	69/25	75/19	0.389
Tumor size, cm (≤5/>5)	48/44	28/63	0.004	38/56	42/52	0.658
Vascular invasion (absent/present)	87/5	85/6	0.767	88/6	89/5	1.000
TNM stage (I/II + III)	72/20	53/38	0.004	63/31	67/27	0.636
Histological grade (I/II/III/other)	71/21	50/41	0.002	68/26	57/37	0.122
GC patients
Gender (male/female)	45/21	51/14	0.237	45/21	50/16	0.439
Tumor size, cm (≤4/>4)	23/43	20/45	0.711	22/44	23/43	1.000
Tumor depth (pT1 + pT2 pT3/pT4)	20/46	21/44	0.852	22/44	24/42	0.855
Lymph node metastasis (pN0 + pN1/pN2 + pN3)	32/34	23/42	0.158	28/38	29/37	1.000
TNM stage (I + II vs. III + IV)	19/47	15/50	0.551	16/50	21/45	0.439
Histological grade (I + II/III/other)	19/42/5	14/45/4	0.637	22/37/6	13/49/4	0.112

HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis
^aData were missing for these variables in some patients: CD204⁺ Mφs, n = 183 and CD169⁺ Mφs, n = 188 in HCC; CD204⁺ Mφs, n = 131 and CD169⁺ Mφs, n = 132 in HCC
^bItalic values indicate significance of p value (p < 0.05)

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