Table 4 Association between eNOS Haplotypes and PFS and OS
eNOS haplotypes | CT + B | CT | ||||||
|---|---|---|---|---|---|---|---|---|
n | Median PFS (95% CI) | HR (95% CI) | P* | n | Median PFS (95% CI) | HR (95% CI) | P* | |
Haplo1/Haplo1 | 24 | 17.8 (8.1–22.3) | 0.46 (0.27–0.78) | 33 | 10.3 (8.0–15.0) | 0.71 (0.46–1.10) | ||
Other | 90 | 9.6 (8.3–10.9) | 1.00 | 0.004 | 86 | 9.0 (7.8–9.6) | 1.00 | 0.123 |
Haplo2/Haplo2 | 15 | 13.1 (7.2–15.7) | 0.82 (0.46–1.46) | 16 | 9.9 (5.9–11.5) | 1.44 (0.82–2.51) | ||
Other | 99 | 9.6 (8.3–11.3) | 1.00 | 0.501 | 107 | 9.0 (8.3–10.2) | 1.00 | 0.199 |
Haplo1/Haplo1 + Haplo2/Haplo2 | 39 | 15.0 (10.6–18.7) | 0.48 (0.30–0.75) | 49 | 10.3 (8.3–11.5) | 0.88 (0.60–1.31) | ||
Other | 75 | 9.1 (7.4–10.1) | 1.00 | 0.001 | 70 | 9.0 (7.2–9.6) | 1.00 | 0.542 |
eNOS haplotypes | CT + B | CT | ||||||
|---|---|---|---|---|---|---|---|---|
n | Median OS (95% CI) | HR (95% CI) | P* | n | Median OS (95% CI) | HR (95% CI) | P* | |
Haplo1/Haplo1 | 24 | 31.6 (19.3–nr) | 0.46 (0.24–0.86) | 33 | 23.2 (16.8–39.7) | 0.80 (0.49–1.31) | ||
Other | 90 | 21.3 (15.9–25.2) | 1.00 | 0.016 | 86 | 20.8 (18.2–24.5) | 1.00 | 0.379 |
Haplo2/Haplo2 | 15 | 34.5 (13.1–42.9) | 0.70 (0.37–1.31) | 16 | 21.3 (14.4–26.4) | 1.35 (0.73–2.50) | ||
Other | 99 | 21.3 (16.4–24.7) | 1.00 | 0.260 | 107 | 21.6 (19.2–27.1) | 1.00 | 0.331 |
Haplo1/Haplo1 + Haplo2/Haplo2 | 39 | 34.5 (23.4–38.4) | 0.42 (0.25–0.72) | 49 | 21.7 (18.8–29.6) | 0.95 (0.61–1.48) | ||
Other | 75 | 20.5 (14.4–22.7) | 1.00 | 0.002 | 70 | 20.8 (18.2–27.1) | 1.00 | 0.829 |