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Table 3 Comparision of glucose usage lactate production and radiation response in the exponentially growing monolayers and as a function of age in spheroids.

From: Establishment and characterization of multicellular spheroids from a human glioma cell line; Implications for tumor therapy

Model Glucose utilization (pico mole/cell/h) Lactate production (pico mole/cell/h) Dq(Gy) D0(Gy) S.F2
Monolayer 0.83 ± 0.03 1.47 ± 0.01 1.2 2.4 0.8 ± 0.04
7 day spheroid 2.10 ± 0.07 3.67 ± 0.04 1.8 3.2 0.9 ± 0.03
28 day spheroid 1.85 ± 0.05 2.93 ± 0.02 2.8 2.7 1.0 ± 0.06
  1. Note: All values are mean ± SD of 6 observations from two experiments