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Table 1 Clinical and laboratory characteristics of all the patients

From: Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

Characteristics

Total (n = 105)

Age, years

31.69 ± 5.65

Male, n (%)

99 (94.3)

BMI, kg/(m2)

29.07 ± 20.14

Family history of premature CAD, n (%)

20 (19.0)

History of MI, n (%)

52 (49.5)

Currently smoking, n (%)

70 (66.7)

Alcohol drinker, n (%)

42 (40.0)

Hypertension, n (%)

46 (43.8)

DM, n (%)

17 (16.2)

Statin, n (%)

81 (77.1)

TG, mmol/L

1.80 ± 0.84

TC, mmol/L

6.62 ± 7.49

HDL-C, mmol/L

0.89 ± 0.26

LDL-C, mmol/L

5.77 ± 3.38

Lp(a), mg/dL

210.40 (65.75–496.06)

Xanthoma, n (%)

12 (11.4)

Mutations, n (%)

40 (38.1)

 LDLR, n (%)

15 (14.3)

 APOB, n (%)

7 (6.7)

 PCSK9, n (%)

2 (1.9)

 STAP1, n (%)

1 (1.0)

 LDLR Homozygote, n (%)

4 (4.8)

 Two mutations, n (%)

11 (10.5)

  1. Data are expressed as mean ± SD, or n (%). BMI body mass index, CAD coronary artery disease, MI myocardial infarction, DM diabetes mellitus, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, Lp(a) lipoprotein (a), APOB apolipoprotein B, LDLR low-density lipoprotein receptor, PCSK9 proprotein convertase subtilisin/Kexin type 9, STAP1 signal-transducing adaptor protein 1