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Table 4 Changes in pre- to postoperative amino acid levels in healthy donors (HD) and breast cancer patients (BrCA)

From: Tumor-dependent increase of serum amino acid levels in breast cancer patients has diagnostic potential and correlates with molecular tumor subtypes

Amino acid

Fold difference pre- to postoperative

 

P-value (group difference)

  

BrCA [n = 38]

p

HD [n = 9]

p

 

Aspartic acid

Asp

1.08 ± 0.51

ns

1.68 ± 0.81

0.013

0.049

Glutamic acid

Glu

1.19 ± 0.57

ns

1.20 ± 0.33

ns

 

Asparagine

Asn

1.30 ± 0.43

0.000

1.48 ± 0.37

0.001

 

Serine

Ser

1.35 ± 0.47

0.000

1.77 ± 0.65

0.000

 

Glutamine

Gln

1.19 ± 0.47

ns

1.89 ± 0.44

0.000

0.004

Citrulline

Cit

1.41 ± 0.53

0.000

1.38 ± 0.47

0.030

 

Arginine

Arg

1.50 ± 1.23

0.000

1.60 ± 0.52

0.002

 

Alanine

Ala

1.44 ± 0.50

0.000

1.90 ± 0.58

0.000

 

Tyrosine

Tyr

1.39 ± 0.57

0.000

1.75 ± 0.77

0.028

 

Valine

Val

1.35 ± 0.49

0.001

1.73 ± 0.59

0.000

 

Phenylalanine

Phe

1.32 ± 0.39

0.000

1.87 ± 0.64

0.000

0.030

Isoleucine

Ile

1.30 ± 0.52

0.007

1.68 ± 0.72

0.003

 

Leucine

Leu

1.42 ± 0.49

0.000

1.81 ± 0.69

0.000

 

Ornithine

Orn

1.51 ± 0.78

0.000

1.95 ± 0.95

0.001

 

Lysine

Lys

1.61 ± 1.61

0.000

2.03 ± 0.60

0.000

 
  1. Fold differences are represented by means and SD. P-values in the respective groups represent the difference between pre- and postoperative value per amino acid; p-values in bold style (right column) represent significant differences in fold change, adjusted for age and BMI, between the two groups (HD and BrCA). ns: not significant. A P-value <0.05 was considered significant.