Integration of gene expression, clinical, and epidemiologic data to characterize Chronic Fatigue Syndrome

Table 2 Identification of differentially expressed genes in CFS subjects by clinical or epidemiologic variables.

Clinical or epidemiologic variable	SAM^a	t-Test^b (unequal variance)	Wilcoxon^b
Type of fatigue onset (gradual or sudden)	117	199	159
Illness group (1 or 2)	0	15	1
Age (≤50 or >50 years)	4	29	22
Body mass index (<25 or >30)	0	4	5
No. of symptoms (4 or ≥6)	0	0	0
Duration of illness (≤10 or >10)	6	19	10

^a Number of genes for which false discovery rate (FDR) = 5% ^b Number of genes for which comparison yielded p < 0.01 ^c The 7 subjects with 5 symptoms (Table 1) were excluded from the analysis of data shown in Table 2. Analysis including these subjects into either group did not significantly affect the outcome.

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