Fig. 1

Effects of PSELT on systemic inflammation and cardiac dysfunction. Plasma levels of A IL-1β and B TNF-α. C Flow cytometry analysis of M1 polarization marker CD80 in RAW 264.7 macrophages untreated (unstained cells, UC) or treated with vehicle (CTRL), LPS (100 ng/ml), LPS + PSELT and PSELT (5 nM) for 24 h. Histograms represent the percentages of CD80 positive cells (n = 4 independent experiments). Plasma levels of D LDH and E BNP, and cardiac levels of F Gal-3 (n = 6) in WST, WST + PSELT, SHHF, SHHF + PSELT groups. Data are expressed as means ± SEM. Significant differences were detected by one-way ANOVA and Newman-Keuls multiple comparison test. *p < 0.05; **p < 0.01; ***p < 0.001