Fig. 6

Prok2R expression levels modulate activation of the Akt/FoxO3a axis. Western blot (WB) images of prok2R/Akt/FoxO3a in prok2R⁺ HEK293T cell lines (a–d). WB images of prok2R/Akt/FoxO3a in prok2R⁻ HEK293T cell lines (e–h). The prok2R/Akt/FoxO3a axis expression levels in the prok2R^vector, prok2R⁺, prok2R⁺ + DMSO, and prok2R⁺ + ipatasertib groups (i–l). Apoptosis-related proteins expressed in different treatment groups (m–p). Significant differences are shown by *p < 0.05, **p < 0.01, ***p < 0.001. n = 3 in each group