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Table 2 Multivariable logistic regression analyses of POAG genetic risk for baseline intraocular pressure, refractive error, and corneal hysteresis (n = 73,548)

From: Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks

 

High IOP

Myopia

Low CH

 

Model 1

Model 2

Model 1

Model 2

Model 1

Model 2

 

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

OR

95% CI

P

POAG PRS

 Low

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Intermediate

1.53 (1.41–1.67)

 < 0.001

1.58 (1.44–1.74)

 < 0.001

1.06 (1.02–1.10)

 < 0.001

1.06 (1.01–1.16)

0.0131

1.09 (1.05–1.14)

 < 0.001

1.07 (1.02–1.12)

< 0.001

 High

2.37 (2.16–2.60)

 < 0.001

2.38 (2.15–2.65)

 < 0.001

1.19 (1.13–1.25)

 < 0.001

1.18 (1.11–1.25)

 < 0.001

1.23 (1.17–1.29)

 < 0.001

1.21 (1.14–1.28)

 < 0.001

 Very high

3.93 (3.17–4.84)

 < 0.001

3.84 (2.98–4.89)

 < 0.001

1.35 (1.16–1.58)

 < 0.001

1.28 (1.06–1.52)

0.0078

1.29 (1.10–1.50)

0.002

1.27 (1.06–1.51)

0.0103

  1. POAG primary open angle glaucoma, PRS polygenic risk score, OR odds ratio, CI confidence interval
  2. Myopia was defined as having a spherical equivalent of ≤ − 0.5D, low corneal hysteresis (CH) as having value of ≤ 10.1 mmHg, and high IOP (intraocular pressure) as having value of ≥ 21 mmHg
  3. Model 1: Age + sex + genotyping array + first ten principal components of ancestry
  4. Model 2: Model 1 + BMI + Income + Smoking + systolic blood pressure + diastolic blood pressure + LDL cholesterol + HbA1c + hypertension
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Journal of Translational Medicine

ISSN: 1479-5876

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