Fig. 1

A The azaspiranic tetracyclic scaffold. B The workflow of this study. C The 119 overlapping targets between SP (353 targets) and STP (420 targets). D PPI networks (115 nodes, 603 edges). E A bubble chart of 37 signaling pathways against pan-cancer. F HSP90AA1—Nordeoxyharringtonine complex. G CASP8—Nordeoxyharringtonine complex. H TLR4—Nordeoxyharringtonine complex. I PRKCD—Nordeoxyharringtonine complex. J Density functional theory (DFT) plot and its energy gap (E_gap) for Nordeoxyharringtonine and conventional anticancer drugs. Red bar was indicated Nordeoxyharringtonine. K The key summary of this study