Fig. 4
From: Amino acid profile alteration in age-related atrial fibrillation
Myocardial untargeted metabolomics between adult AF (Group B, BadAF) and aged AF (Group D, DagAF) mice. A–B Volcano plot of the different metabolites in univariate analysis (FC > 1.5 or < 0.67, and t-test P-value < 0.05) in A positive ion mode and B negative ion mode. C–D Orthogonal partial least-squares discriminant analysis (OPLS-DA) score plot in C positive ion mode and D negative ion mode. E Hierarchical clustering heatmap of metabolites with significant differences (OPLS-DA VIP value > 1 and t-test P-value < 0.05, with qualitative names) in positive ion mode. F Top 20 enriched KEGG pathways of the significantly different metabolites in positive ion mode. n = 10 in each group