Fig. 3
From: Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Therapeutic effects of NMN on liver and kidney injury in septic mice. After an hour of FIP (3 g feces/kg body weight), mice were intraperitoneally administrated with NMN. Six hours after FIP, blood and liver and kidney tissues were harvested. A–C MDA level, protein carbonyl and MPO activity were determined in liver tissues. D-F MDA level, protein carbonyl and MPO activity were determined in kidney tissues. ALT (G), AST (H), creatinine (I) and BUN (J) in sera were measured. Data are mean ± SD, n = 8 mice in each group. *P < 0.05 vs saline + vehicle and #P < 0.05 vs feces + vehicle (One-way ANOVA followed by Newman–Keuls test)