Mutated pathwayn and other factors | Number | Disease-free survival in KRASmut (n=458) | Overall survival in KRASmut (n=458) | ||||
---|---|---|---|---|---|---|---|
Median (mo) | HR (95% CI) | P | Median (mo) | HR [95% CI] | P | ||
KRASÂ | |||||||
 G12D | 220 (48.0%) | 11.83 [9.65–14.01] | 1 [Reference] | 1 | 21.07 [18.49–23.65] | 1 [Reference] | 1 |
 Other codon | 238 (52.0%) | 13.97 [11.93–16.01] | 0.823 [0.663–1.020] | 0.075 | 23.30 [21.79–24.81] | 0.839 [0.665–1.059] | 0.139 |
TP53 | |||||||
 WT | 164 (35.8%) | 17.30 [14.88–19.72] | 1 [Reference] | 1 | 26.97 [20.98–32.96] | 1 [Reference] | 1 |
  Mutated | 294 (64.2%) | 10.60 [9.14–12.06] | 1.390 [1.102–1.752] | 0.005 | 21.03 [18.54–23.52] | 1.287 [1.003–1.651] | 0.047 |
Cell cycle | |||||||
 WT | 376 (82.1%) | 13.90 [11.70–16.10] | 1 [Reference] | 1 | 23.30 [21.19–25.41] | 1 [Reference] | 1 |
 Mutated | 82 (17.9%) | 10.60 [7.97–13.23] | 1.388 [1.059–1.818] | 0.017 | 19.23 [16.33–22.13] | 1.385 [1.034–1.855] | 0.029 |
TGFb | |||||||
 WT | 365 (79.7%) | 13.63 [11.54 – 15.72] | 1 [Reference] | 1 | 23.23 [21.19–25.27] | 1 [Reference] | 1 |
 Mutated | 93 (20.3%) | 10.07 [7.01 - 13.13] | 1.201 [0.929–1.552] | 0.162 | 18.77 [14.42–23.12] | 1.165 [0.883–1.537] | 0.280 |
Trithorax | |||||||
 WT | 362 (79.0%) | 12.93 [10.96 - 14.90] | 1 [Reference] | 1 | 22.43 [20.54–24.32] | 1 [Reference] | 1 |
 Mutated | 96 (21.0%) | 12.83 [9.76 - 15.90] | 0.917 [0.705–1.193] | 0.519 | 23.10 [20.18–26.02] | 0.903 [0.656–1.243] | 0.532 |
Male | 273 (59.6%) |  | 1.198 [0.966–1.485] | 0.099 |  | 1.153 [0.912–1.458] | 0.233 |
Age > 70y | 108 (23.6%) |  | 1.070 [0.814–1.407] | 0.627 |  | 1.061 [0.785–1.435] | 0.699 |
Vascular invasion | 159 (34.7%) |  | 1.209 [0.952–1.537] | 0.120 |  | 1.243 [0.962–1.604] | 0.096 |
Poor differentiated | 228 (49.8%) |  | 1.573 [1.270–1.949] | <0.001 |  | 1.645 [1.303–2.076] | <0.001 |
Tumor >3cm | 170 (37.1%) |  | 1.439 [1.139–1.816] | 0.002 |  | 1.336 [1.046–1.706] | 0.020 |
N1-2 | 240 (52.4%) |  | 1.412 [1.140–1.749] | 0.002 |  | 1.497 [1.189–1.885] | 0.001 |
R1 margin status | 72 (15.7%) |  | 1.211 [0.902–1.625] | 0.203 |  | 1.395 [1.024–1.899] | 0.035 |
Chemotherapy | 329 (71.8%) |  | 0.571 [0.443–0.736] | <0.001 |  | 0.042 [0.304–0.531] | <0.001 |