From: A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification
Gene symbol | Ubiquitination site | Fold change | Description |
---|---|---|---|
Up-ubiquitination modification | Â | ||
 ACSL4 | K702 | 6.02 | Long-chain-fatty-acid–CoA ligase 4 |
K401 | 28.94 | Â | |
 ACTB | K328 | 4.97 | Actin, cytoplasmic 1 |
 AHCY | K188 | 2.24 | Adenosylhomocysteinase |
 AKAP2 | K448 | 5.23 | A-kinase anchor protein 2 |
 ALDOA | K42 | 2.33 | Fructose-bisphosphate aldolase A |
 ANKRD13A | K247 | 11.82 | Ankyrin repeat domain-containing protein 13A |
K219 | 7.93 | Â | |
 APBB1 | K48 | 5.79 | Amyloid beta precursor protein binding family B member 1 |
 CAVIN1 | K170 | 17.71 | Caveolae-associated protein 1 |
K122 | 9.64 | Â | |
 CCDC50 | K129 | 1.43 | Coiled-coil domain-containing protein 50 |
 CDC20 | K490 | 6.30 | Cell division cycle protein 20 homolog |
 CHIC1 | K176 | 5.05 | Cysteine-rich hydrophobic domain-containing protein 1 |
 CLIC4 | K199 | 1.94 | Chloride intracellular channel protein 4 |
 CRIM1 | K978 | 3.64 | Cysteine-rich motor neuron 1 protein |
 CSDE1 | K91 | 3.37 | Cold shock domain-containing protein E1 |
 CUEDC1 | K318 | 2.31 | CUE domain-containing protein 1 |
 CYB5R3 | K163 | 3.92 | NADH-cytochrome b5 reductase 3 |
 CYP1B1 | K454 | 3.57 | Cytochrome P450 1B1 |
 DAG1 | K793 | 4.68 | Dystroglycan 1 |
K782 | 31.67 | Â | |
 DCBLD2 | K560 | 1.70 | Discoidin, CUB and LCCL domain-containing protein 2 |
 EEF2 | K272 | 8.43 | Elongation factor 2 |
K239 | 1.66 | Â | |
 EHMT1 | K827 | 3.33 | Histone-lysine N-methyltransferase EHMT1 |
 EPS15L1 | K531 | 3.80 | Epidermal growth factor receptor substrate 15-like 1 |
 FADS2 | K409 | 3.58 | Acyl-CoA 6-desaturase |
K28 | 22.75 | Â | |
K108 | 5.67 | Â | |
 GABARAP | K13 | 4.36 | Gamma-aminobutyric acid receptor-associated protein |
 GAPDH | K194 | 3.77 | Glyceraldehyde-3-phosphate dehydrogenase |
 GJA1 | K303 | 16.95 | Gap junction alpha-1 protein |
K258 | 5.67 | Â | |
K128 | 7.89 | Â | |
 GNAI2 | K46 | 2.26 | Guanine nucleotide-binding protein G(i) subunit alpha-2 |
 GPRC5A | K348 | 4.93 | Retinoic acid-induced protein 3 |
 GRB2 | K109 | 1.92 | Growth factor receptor-bound protein 2 |
 H1-5 | K93 | 8.22 | Histone H1.5 |
K88 | 2.86 | Â | |
 HMGCR | K248 | 2.50 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
 HNRNPA1 | K350 | 12.44 | Heterogeneous nuclear ribonucleoprotein A1 |
 HNRNPK | K198 | 2.54 | Heterogeneous nuclear ribonucleoprotein K |
 HSP90AA1 | K443 | 6.15 | Heat shock protein HSP 90-alpha |
K362 | 19.99 | Â | |
 HSPA8 | K71 | 2.91 | Heat shock cognate 71 kDa protein |
 IFNGR1 | K285 | 4.02 | Interferon gamma receptor 1 |
 ITGB1 | K794 | 7.85 | Integrin beta-1 |
 JAK1 | K504 | 12.53 | Tyrosine-protein kinase JAK1 |
K227 | 8.53 | Â | |
 LMNA | K270 | 11.70 | Prelamin-A/C |
 LMNB1 | K389 | 4.70 | Lamin-B1 |
K102 | 6.05 | Â | |
 LSS | K432 | 1.97 | Lanosterol synthase |
 MAGED1 | K656 | 4.57 | Melanoma-associated antigen D1 |
 MCL1 | K40 | 2.22 | Induced myeloid leukemia cell differentiation protein Mcl-1 |
 MMP15 | K662 | 9.19 | Matrix metalloproteinase-15 |
 MTA2 | K611 | 4.24 | Metastasis-associated protein MTA2 |
 MYH10 | K689 | 2.02 | Myosin-10 |
 MYRF | K749 | 3.47 | Myelin regulatory factor |
 NCKAP1 | K12 | 6.03 | Nck-associated protein 1 |
 NDFIP2 | K193 | 2.11 | NEDD4 family-interacting protein 2 |
 NEDD4 | K874 | 17.30 | E3 ubiquitin-protein ligase NEDD4 |
 NME2 | K12 | 7.44 | Nucleoside diphosphate kinase B |
K100 | 1.69 | Â | |
 NONO | K198 | 2.76 | Non-POU domain-containing octamer-binding protein |
 OTUB1 | K84 | 1.42 | Ubiquitin thioesterase OTUB1 |
 PABPC4 | K188 | 3.04 | Polyadenylate-binding protein 4 |
 PI4K2A | K240 | 5.04 | Phosphatidylinositol 4-kinase type 2-alpha |
 PKM | K270 | 1.89 | Pyruvate kinase PKM |
 PLCXD1 | K227 | 2.31 | PI-PLC X domain-containing protein 1 |
 PPP2R1B | K200 | 6.95 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
 PRKAR1A | K261 | 3.80 | cAMP-dependent protein kinase type I-alpha regulatory subunit |
 PSMA7 | K115 | 3.09 | Proteasome subunit alpha type-7 |
 PSMB3 | K77 | 7.85 | Proteasome subunit beta type-3 |
 PSMC3 | K245 | 6.84 | 26S proteasome regulatory subunit 6A |
 PSMC5 | K94 | 1.37 | 26S proteasome regulatory subunit 8 |
 PSMD2 | K66 | 2.17 | 26S proteasome non-ATPase regulatory subunit 2 |
 PTBP1 | K508 | 4.84 | Polypyrimidine tract-binding protein 1 |
 RAB5C | K117 | 17.55 | Ras-related protein Rab-5C |
 RACGAP1 | K292 | 1.95 | Rac GTPase-activating protein 1 |
 RACK1 | K106 | 3.77 | Receptor of activated protein C kinase 1 |
 RAD18 | K218 | 2.00 | E3 ubiquitin-protein ligase RAD18 |
 RDX | K79 | 2.07 | Radixin |
 RNF114 | K126 | 4.31 | E3 ubiquitin-protein ligase RNF114 |
 RNF167 | K272 | 1.61 | E3 ubiquitin-protein ligase RNF167 |
 RPL12 | K61 | 4.28 | 60S ribosomal protein L12 |
 RPL24 | K93 | 2.45 | 60S ribosomal protein L24 |
K27 | 3.73 | Â | |
 RPL3 | K286 | 3.50 | 60S ribosomal protein L3 |
 RPL30 | K26 | 5.15 | 60S ribosomal protein L30 |
 RPL31 | K70 | 4.31 | 60S ribosomal protein L31 |
 RPL6 | K262 | 2.49 | 60S ribosomal protein L6 |
 RPL7A | K48 | 2.17 | 60S ribosomal protein L7a |
K245 | 4.07 | Â | |
 RPS17 | K19 | 11.59 | 40S ribosomal protein S17 |
 RPS27A | K6 | 2.12 | Ubiquitin-40S ribosomal protein S27a |
 RPS3 | K141 | 2.02 | 40S ribosomal protein S3 |
 RPSA | K89 | 5.62 | 40S ribosomal protein SA |
 RRM1 | K376 | 2.47 | Ribonucleoside-diphosphate reductase large subunit |
 SCD | K341 | 6.02 | Stearoyl-CoA desaturase |
 SCP2 | K438 | 9.43 | Sterol carrier protein 2 |
 SFPQ | K421 | 2.20 | Splicing factor, proline- and glutamine-rich |
 SGTA | K200 | 8.44 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
K160 | 9.16 | Â | |
 SLC20A1 | K389 | 1.78 | Sodium-dependent phosphate transporter 1 |
 SMARCA5 | K929 | 6.41 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 |
 SPART | K481 | 2.37 | Spartin |
 SPTLC1 | K197 | 4.47 | Serine palmitoyltransferase 1 |
 SUV39H1 | K138 | 5.91 | Histone-lysine n-methyltransferase SUV39H1 |
 SYNCRIP | K363 | 17.81 | Heterogeneous nuclear ribonucleoprotein Q |
 TCAF1 | K817 | 11.59 | TRPM8 channel-associated factor 1 |
 TMUB1 | K129 | 2.73 | Transmembrane and ubiquitin-like domain-containing protein 1 |
K108 | 4.00 | Â | |
 TNFRSF1A | K242 | 7.92 | Tumor necrosis factor receptor superfamily member 1A |
 TPD52L2 | K108 | 1.74 | Tumor protein D54 |
 TPM1 | K37 | 1.51 | Tropomyosin alpha-1 chain |
 TPR | K290 | 2.67 | Nucleoprotein TPR |
 UBE2L3 | K73 | 2.11 | Ubiquitin-conjugating enzyme E2 L3 |
 UBE2N | K82 | 8.56 | Ubiquitin-conjugating enzyme E2 N |
 UBE2O | K132 | 5.16 | (E3-independent) E2 ubiquitin-conjugating enzyme |
 UBE2T | K91 | 2.10 | Ubiquitin-conjugating enzyme E2 T |
K48 | 2.74 | Â | |
 UBE3A | K330 | 1.88 | Ubiquitin-protein ligase E3A |
 UBTD2 | K68 | 2.88 | Ubiquitin domain-containing protein 2 |
 UCK2 | K78 | 7.42 | Uridine-cytidine kinase 2 |
 USP14 | K441 | 8.10 | Ubiquitin carboxyl-terminal hydrolase 14 |
 USP25 | K444 | 5.44 | Ubiquitin carboxyl-terminal hydrolase 25 |
K201 | 2.12 | Â | |
 USP5 | K423 | 5.82 | Ubiquitin carboxyl-terminal hydrolase 5 |
 VAMP3 | K35 | 6.18 | Vesicle-associated membrane protein 3 |
 VCP | K658 | 15.10 | Transitional endoplasmic reticulum ATPase |
K236 | 14.68 | Â | |
 VIM | K445 | 4.05 | Vimentin |
 WIZ | K1597 | 5.95 | Protein Wiz |
 YWHAZ | K49 | 3.87 | 14-3-3 protein zeta/delta |
 ZFYVE16 | K1257 | 46.92 | Zinc finger FYVE domain-containing protein 16 |
Down-ubiquitination modification | Â | ||
 SLC4A7 | K548 | 0.17 | Sodium bicarbonate cotransporter 3 |
K31 | 0.39 | Â | |
 RNF114 | K161 | 0.14 | E3 ubiquitin-protein ligase RNF114 |
UBQLN1 | K47 | 0.36 | Ubiquilin-1 |
 TNFRSF10D | K241 | 0.29 | Tumor necrosis factor receptor superfamily member 10D |
 UBAP1 | K177 | 0.56 | Ubiquitin-associated protein 1 |
 FANCI | K523 | 0.39 | Fanconi anemia group I protein |
 ACBD3 | K386 | 0.43 | Golgi resident protein GCP60 |
 FAM234A | K15 | 0.61 | Protein FAM234A |
 RNF5 | K93 | 0.36 | E3 ubiquitin-protein ligase RNF5 |
 SLC29A1 | K263 | 0.56 | Equilibrative nucleoside transporter 1 |
K255 | 0.63 | Â | |
K249 | 0.54 | Â | |
 PKP4 | K518 | 0.44 | Plakophilin-4 |
 UIMC1 | K31 | 0.19 | BRCA1-A complex subunit RAP80 |
 DCUN1D1 | K149 | 0.49 | DCN1-like protein 1 |
 RNF185 | K105 | 0.25 | E3 ubiquitin-protein ligase RNF185 |
 STAM | K171 | 0.64 | Signal transducing adapter molecule 1 |
 MICAL1 | K1036 | 0.39 | [F-actin]-monooxygenase MICAL1 |
 UBA3 | K147 | 0.27 | NEDD8-activating enzyme E1 catalytic subunit |
 SLC43A3 | K264 | 0.25 | Equilibrative nucleobase transporter 1 |
K255 | 0.19 | Â | |
K249 | 0.31 | Â | |
 KTN1 | K256 | 0.42 | Kinectin |
 H2AC25 | K96 | 0.38 | Histone H2A type 3 |
 SV2A | K143 | 0.45 | Synaptic vesicle glycoprotein 2A |
 TUBA1A | K60 | 0.24 | Tubulin alpha-1A chain |
 ZDHHC20 | K96 | 0.24 | Palmitoyltransferase ZDHHC20 |
 H2BC21 | K109 | 0.56 | Histone H2B type 2-E |
 H2AC20 | K119 | 0.57 | Histone H2A type 2-C |
 VAMP3 | K42 | 0.38 | Vesicle-associated membrane protein 3 |
 UBE2V2 | K72 | 0.45 | Ubiquitin-conjugating enzyme E2 variant 2 |
 SLC1A5 | K10 | 0.46 | Neutral amino acid transporter B(0) |
 ABRAXAS2 | K229 | 0.35 | BRISC complex subunit Abraxas 2 |
 EIF3A | K420 | 0.36 | Eukaryotic translation initiation factor 3 subunit A |
 ADAM9 | K781 | 0.51 | Disintegrin and metalloproteinase domain-containing protein 9 |
 TRIM28 | K750 | 0.04 | Transcription intermediary factor 1-beta |
 CALCOCO2 | K339 | 0.25 | Calcium-binding and coiled-coil domain-containing protein 2 |
 AHNAK | K4945 | 0.50 | Neuroblast differentiation-associated protein AHNAK |
 SLC20A2 | K262 | 0.37 | Sodium-dependent phosphate transporter 2 |
 GFPT1 | K48 | 0.20 | Glutamine–fructose-6-phosphate aminotransferase 1 |
 UBE3A | K323 | 0.55 | Ubiquitin-protein ligase E3A |
 UBXN1 | K83 | 0.49 | UBX domain-containing protein 1 |
 RPL19 | K186 | 0.41 | 60S ribosomal protein L19 |
 BASP1 | K38 | 0.33 | Brain acid soluble protein 1 |
 PRKDC | K810 | 0.36 | DNA-dependent protein kinase catalytic subunit |
 UBE2L3 | K96 | 0.40 | Ubiquitin-conjugating enzyme E2 L3 |
K82 | 0.21 | Â | |
K138 | 0.67 | Â | |
K131 | 0.46 | Â | |
 YBX1 | K137 | 0.69 | Y-box-binding protein 1 |
 YWHAZ | K9 | 0.60 | 14-3-3 protein zeta/delta |
 RPS27A | K27 | 0.75 | Ubiquitin-40S ribosomal protein S27a |
 HNRNPK | K422 | 0.10 | Heterogeneous nuclear ribonucleoprotein K |
 SUMO2 | K33 | 0.42 | Small ubiquitin-related modifier 2 |
 UBE2M | K92 | 0.68 | NEDD8-conjugating enzyme Ubc12 |
 RPS20 | K8 | 0.56 | 40S ribosomal protein S20 |
 VCP | K251 | 0.27 | Transitional endoplasmic reticulum ATPase |
K231 | 0.62 | Â | |
K109 | 0.56 | Â | |
 SLC12A2 | K976 | 0.30 | Solute carrier family 12 member 2 |
RAD23B | K51 | 0.46 | UV excision repair protein RAD23 homolog B |
 ATXN3 | K200 | 0.72 | Ataxin-3 |
 SLC16A1 | K473 | 0.17 | Monocarboxylate transporter 1 |
K224 | 0.41 | Â | |
 CAPZB | K267 | 0.25 | F-actin-capping protein subunit beta |
 NEDD4 | K882 | 0.47 | E3 ubiquitin-protein ligase NEDD4 |
 RPS10 | K138 | 0.38 | 40S ribosomal protein S10 |
K139 | 0.50 | Â | |
 RPS9 | K155 | 0.63 | 40S ribosomal protein S9 |
USP5 | K360 | 0.72 | Ubiquitin carboxyl-terminal hydrolase 5 |
 SLC1A4 | K528 | 0.14 | Neutral amino acid transporter A |
K501 | 0.05 | Â | |
K493 | 0.14 | Â | |
K484 | 0.17 | Â | |
K3 | 0.29 | Â | |
 PEX19 | K52 | 0.34 | Peroxisomal biogenesis factor 19 |
 BSG | K366 | 0.22 | Basigin |
 RDX | K526 | 0.48 | Radixin |
 SLC6A6 | K19 | 0.31 | Sodium- and chloride-dependent taurine transporter |
 GNA11 | K107 | 0.44 | Guanine nucleotide-binding protein subunit alpha-11 |
 MARCKS | K11 | 0.20 | Myristoylated alanine-rich C-kinase substrate |
 MSN | K165 | 0.28 | Moesin |
K162 | 0.31 | Â | |
K139 | 0.47 | Â | |
 ATP2B4 | K735 | 0.34 | Plasma membrane calcium-transporting ATPase 4 |
 CFL1 | K144 | 0.48 | Cofilin-1 |
 RPS3 | K214 | 0.42 | 40S ribosomal protein S3 |
 PAM | K901 | 0.62 | Peptidyl-glycine alpha-amidating monooxygenase |
 TCP1 | K541 | 0.43 | T-complex protein 1 subunit alpha |
 PRKCA | K316 | 0.54 | Protein kinase C alpha type |
 STMN1 | K52 | 0.35 | Stathmin |
 H1-3 | K65 | 0.45 | Histone H1.3 |
K35 | 0.52 | Â | |
 H1-5 | K49 | 0.71 | Histone H1.5 |
K37 | 0.43 | Â | |
 H2AX | K128 | 0.45 | Histone H2AX |
 RPS2 | K58 | 0.37 | 40S ribosomal protein S2 |
 CD46 | K375 | 0.49 | Membrane cofactor protein |
 EZR | K139 | 0.65 | Ezrin |
 XRCC5 | K195 | 0.07 | X-ray repair cross-complementing protein 5 |
 PCNA | K164 | 0.52 | Proliferating cell nuclear antigen |
 HSPA8 | K524 | 0.57 | Heat shock cognate 71 kDa protein |
 CNP | K261 | 0.22 | 2′,3′-cyclic-nucleotide 3′-phosphodiesterase |
 VIM | K188 | 0.34 | Vimentin |
 SLC3A2 | K147 | 0.52 | 4F2 cell-surface antigen heavy chain |
 LDHB | K308 | 0.20 | l-lactate dehydrogenase B chain |
 RPN1 | K538 | 0.42 | Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1 |
 HLA-A | K340 | 0.39 | HLA class I histocompatibility antigen, A alpha chain |
K364 | 0.09 | Â | |
K200 | 0.37 | Â | |
 LMNA | K97 | 0.26 | Prelamin-A/C |
K180 | 0.51 | Â | |
 NRAS | K128 | 0.31 | GTPase NRas |
 TDP2 | K82 | 0.35 | Tyrosyl-DNA phosphodiesterase 2 |
 MPZL1 | K213 | 0.74 | Myelin protein zero-like protein 1 |
 UBXN7 | K84 | 0.03 | UBX domain-containing protein 7 |
 SLC16A7 | K463 | 0.23 | Monocarboxylate transporter 2 |
 NUDT21 | K29 | 0.55 | Cleavage and polyadenylation specificity factor subunit 5 |
 EPB41L2 | K374 | 0.58 | Band 4.1-like protein 2 |
K144 | 0.17 | Â | |
K114 | 0.34 | Â | |
 SLC16A3 | K448 | 0.49 | Monocarboxylate transporter 4 |
K431 | 0.44 | Â | |
K428 | 0.39 | Â | |
 SLC16A4 | K244 | 0.18 | Monocarboxylate transporter 5 |
 SCAMP1 | K89 | 0.55 | Secretory carrier-associated membrane protein 1 |
 SCAMP3 | K101 | 0.00 | Secretory carrier-associated membrane protein 3 |
 EEF2K | K341 | 0.18 | Eukaryotic elongation factor 2 kinase |
 CLIC1 | K119 | 0.31 | Chloride intracellular channel protein 1 |