LncRNAs/miRNAs | Potential therapeutic approaches | Anti-tumor effect | Source |
---|---|---|---|
miR-7 | Upregulated by Curcumin | Triggered cell cycle arrest and apoptosis, retarded cell proliferation, migration and invasion by inhibiting Skp2 | [196] |
miR17-5p | Downregulation | Suppressed tumour proliferation via regulation of p21 protein | |
miR-20a-5p | Downregulation | Enhance radiosensitivity via regulation of neuronal PAS domain protein 2 (NPAS2) gene | [199] |
miR-26b | Upregulation | Enhance chemosensitivity (Cisplatin) by inhibiting JAG1 expression | [200] |
miR29-c | Upregulated by knockdown of lncRNA X inactive-specific transcript (XIST) or HMG-box transcription factor 1 (HBP1) | Suppressed cell proliferation and enhance radiosensitive via reduce level of cyclin D1 and cyclin D3 | |
miR-93 | Downregulation | Suppressed tumour growth and migration | [203] |
miR-101 | Upregulation | Suppressed metastasis and angiogenesis by negative regulation of integrin subunit alpha 3 (ITGA3) or Stathmin 1 (STMN1) | |
miR-148b | Upregulation | Suppressed invasion, and metastasis by inhibiting metastasis-related gene 2 (MTA2) | [205] |
miR-149 | Downregulation | Suppressed proliferation, invasion and metastasis via the upregulation of plakophilin3 (PKP3) expression | [187] |
miR-150 | Upregulation | Suppressed cell proliferation and G1/S transition by targeting CCND1, CCND2, CDK2 and CCNE2 | [206] |
miR-185-3p | Upregulation | Enhance radiosensitivity through inhibition of mothers against decapentaplegic homolog 7 (SMAD7) | [207] |
miR-205 | Downregulation | Suppressed tumour growth and migration | [203] |
miR-212 | Upregulation | Suppressed invasion and migration by targeting SRY-Box Transcription Factor 4 (SOX4) | [208] |
miR-324-3p | Upregulation | Suppressed invasion, cell proliferation, apoptosis by negative regulation of GLI Family Zinc Finger 3 (GLI3) gene | [209] |
miR-422a | Upregulation | Suppressed EMT and metastasis by targeting FOXQ1 | [186] |
miR-432 | Upregulation | Suppressed invasion and migration by regulation E2F transcription factor 3 (E2F3) expression | [210] |
miR-504 | Downregulation | Enhance radiosensitivity via upregulation of NRF1 | [185] |
LncRN UCA1 | Downregulation | Suppressed invasion and cell proliferation via miR-145/A disintegrin and metalloprotease 17 (ADAM17) axis | [188] |
LncRN CASC9 | Downregulation | Suppressed the cancer progression by destabilising the HIF1α | [189] |
LncRN AFAP1-AS1 | Downregulation | Prevent to be co-expressed with PD-1 to promote immune escape | [211] |
LncRN MEG3 | Upregulation | Induced cell cycle arrest, inhibited cell proliferation and colony formation | [192] |
LncRN PVT1 | Downregulation | Enhance radiosensitivity via regulation of DNA damage repair pathway | [191] |
LncRN ANCR | Downregulation | Enhance radiosensitivity via regulation of PTEN expression | [183] |
LncRN MALAT1 | Downregulation | Enhance radiosensitivity via regulation of miR-1/slug axis | [184] |
LncRN NEAT1 | Downregulation | Suppressed tumourigenesis and enhance chmeosensitivity (cisplatin) via regulation of miR-124 and Rsf-1/Ras-MAPK/let-7a-5p axis | [182] |
LncRNA LINC00460 | Downregulation | Suppressed EMT via regulation of miR-30a-3p/Ras-related protein 1A (Rap1A) axis | [212] |
LncRNA NKILA | Upregulation | Suppressed carcinogenesis through the inhibition of NF-κB signalling | [213] |
LncRNA FAM225A | Downregulation | Suppressed cell proliferation and invasion by regulation of ITGB3 and FAK/PI3K/Akt pathways | [194] |
LncRNA DRAIC | Downregulation | Suppressed invasion and migration by miR-122/SATB1 axis | [214] |
LncRNA TP73-AS1 | Downregulation | Suppressed migration and invasion via regulation of miR-495/JAM-A axis | [215] |
LncRNA FOXD3-AS1 | Downregulation | Suppressed colony formation, invasion and migration via regulation of miR-185-3p/FOXD3 axis | [195] |