Fig. 1

PV001-DV exhibits direct oncolytic effect on human melanoma cell lines. A Schematic of A2058 human melanoma cells incubated with PV001-DV (DV) and measured for viability. B Photomicrograph of cells at 10X magnification from A at 3 days of incubation. C Percent Propidium Iodide (PI) and percent ApoTracker staining of cells from A at 6 days. *P < 0.05, **P < 0.01, ***P < 0.001, One-way ANOVA with Tukey correction. D Division of cells from (A) into viable, early apoptotic, late apoptotic/necrotic, and necrotic based on combination PI and ApoTracker staining. E Schematic of SK-MEL-2 and SK-MEL-28 melanoma cells incubated with PV001-DV (DV) and measured for viability. F Flow cytometry histograms of viability via Aqua Live/Dead staining from experiment in E. G Bar graphs of viability from experiment in E