From: Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis
Name | Main function | Sensitive materials | Location | References |
---|---|---|---|---|
TRPV1 | Regulation: Temperature; Pressure; Osmotic pressure; pH | Capsaicin; Heat; Na+; Ca2+; Acidosis; H+; Endogenous agonists | Variety of tissues and cell types | |
TRPV2 | Regulation: Temperature Cell migration; Innate immune system | Ca2+; Heat | Skeletal muscle; Cardiac muscle; Neurons; Heart; Gastrointestinal tract; Lung; Pancreas; Retina; Brain | |
TRPV3 | Regulation: Temperature; Synaptic plasticity | Ca2+; Bradykinin; Histamine; ATP; PKC; PGE2; a-hydroxyl acids; 2-APB; PIP2; Heat | Tongue; Testis; Skin keratinocytes | |
TRPV4 | Regulation: Mechanical; Osmotic pressure | Ca2+; Heat | Chondrocyte; Adipocytes; Vascular endothelium; Retina; Neurons | |
TRPV5 | Regulation: pH; Ca2+selective TRP channel; Inward rectification of the current- voltage | Ca2+; E2; 1,25-(OH)2D3; Calcitonin; Klotho; PTH; Testosterone; Vasopressin; MUC1; PIP2 | Bone; Kidney; Placenta | |
TRPV6 | Regulation: Ca2+selective TRP channel | Ca2+; 1,25-(OH)2D3; Ba2+; Sr2+; Mn2+; Zn2+; Cd2+; La3+; Gd3+; PIP2 | Intestinal enterocytes; Kidney; Placenta; Uterus; Pancreas; Epididymal epithelium; Brain; Stomach |