Locus | Lead SNP | CHR | A1/A2 | BP | Cross-trait analysis | FRQ | Nearest Gene | Functional category | Overlap with original GWAS IBS | Overlap with previous GWAs on psychiatric traits | Overlap with previous GWAs | CADD | RDB | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta | SE | P | |||||||||||||
1 | rs301806 | 1 | T/C | 8482078 | − 0.009 | 0.002 | 1.67E-09 | 0.58 | RERE | Intronic | NO | Neuroticism | Known | 0.117 | 4 |
2 | rs11206127 | 1 | A/G | 53713549 | − 0.009 | 0.002 | 1.42E-08 | 0.43 | LRP8 | Intronic | NO | No | Novel | 0.128 | 6 |
3 | rs12755507 | 1 | T/C | 176164865 | 0.01 | 0.002 | 8.03E-10 | 0.625 | RFWD2 | Intronic | NO | Depression | Known | 6.038 | 4 |
4 | rs113198479 | 1 | A/G | 191347803 | − 0.02 | 0.004 | 2.48E-08 | 0.953 | RP11-309H21.2 | Intergenic | NO | No | Novel | 1.241 | 6 |
5 | rs72740550 | 1 | A/G | 197342380 | − 0.011 | 0.002 | 6.02E-09 | 0.219 | CRB1 | Intronic | NO | Neuroticism & depression | Known | 5.063 | 7 |
6 | rs115962846 | 2 | A/G | 58967058 | − 0.015 | 0.003 | 3.68E-08 | 0.912 | LINC01122 | ncRNA_intronic | NO | Neuroticism | Known | 2.103 | 7 |
7 | rs28496790 | 2 | A/C | 161950047 | 0.01 | 0.002 | 3.70E-09 | 0.708 | AC009313.1 | Intergenic | NO | No | Novel | 6.027 | 5 |
8 | rs138218528 | 2 | T/C | 212676884 | 0.009 | 0.002 | 2.84E-08 | 0.667 | ERBB4 | Intronic | NO | Neuroticism & depression | Known | 8.481 | 6 |
9 | rs62246276 | 3 | T/G | 9445173 | − 0.011 | 0.002 | 2.28E-08 | 0.179 | SETD5 | Intronic | NO | No | Novel | 1.944 | 5 |
10 | rs67416405 | 3 | T/C | 85539234 | − 0.009 | 0.002 | 8.27E-09 | 0.353 | CADM2 | Intronic | YES | No | Known | 3.769 | 6 |
11 | rs1729951 | 3 | T/G | 136500733 | − 0.009 | 0.002 | 9.01E-09 | 0.389 | RP11-102M11.2 | Intergenic | NO | Neuroticism | Known | 0.078 | NA |
12 | rs1442129 | 4 | A/G | 90849446 | − 0.009 | 0.002 | 1.22E-08 | 0.453 | MMRN1 | Intronic | NO | No | Novel | 5.378 | NA |
13 | rs77087420 | 4 | A/G | 123122856 | 0.018 | 0.003 | 2.64E-08 | 0.945 | KIAA1109 | Intronic | NO | No | Novel | 4.579 | 7 |
14 | rs12513440 | 5 | A/G | 7259853 | 0.01 | 0.002 | 2.73E-08 | 0.243 | RP11-404K5.3 | Intergenic | NO | No | Novel | 0.327 | 5 |
15 | rs3099439 | 5 | T/C | 87545318 | − 0.011 | 0.002 | 1.14E-12 | 0.539 | TMEM161B | Intronic | NO | Depression | Known | 1.562 | NA |
16 | rs4481363 | 5 | A/C | 164474719 | 0.009 | 0.001 | 1.01E-09 | 0.524 | CTC-340A15.2 | ncRNA_intronic | NO | Neuroticism & depression | Known | 6.522 | 6 |
16 | rs180928232 | 5 | A/G | 166185949 | − 0.012 | 0.002 | 4.46E-08 | 0.149 | CTB-7E3.1 | Intergenic | NO | Neuroticism | Known | 2.692 | 6 |
17 | rs200977 | 6 | T/C | 27854301 | 0.015 | 0.002 | 1.04E-11 | 0.873 | HIST1H3J | Intergenic | NO | Neuroticism & depression | Known | 1.251 | NA |
17 | rs2534664 | 6 | A/G | 31469591 | 0.01 | 0.002 | 2.63E-10 | 0.456 | MICB | Intronic | NO | Depression | Known | 3.484 | NA |
17 | rs1144708 | 6 | T/C | 31710020 | − 0.01 | 0.002 | 7.49E-10 | 0.357 | MSH5:MSH5-SAPCD1 | Intronic | YES | No | Known | 0.372 | 6 |
18 | rs12374612 | 6 | T/C | 100955752 | 0.009 | 0.001 | 1.02E-08 | 0.478 | ASCC3 | Downstream | NO | Neuroticism | Known | 0.29 | 6 |
19 | rs2189246 | 7 | A/G | 82444372 | 0.01 | 0.001 | 1.98E-10 | 0.523 | PCLO | Intronic | NO | Depression | Known | 1.139 | 7 |
20 | rs6956352 | 7 | A/G | 109131367 | 0.009 | 0.002 | 1.64E-08 | 0.458 | AC073071.1 | Intergenic | NO | Depression | Known | 9.195 | 7 |
21 | rs4726814 | 7 | T/C | 146691924 | − 0.01 | 0.002 | 1.30E-08 | 0.275 | CNTNAP2 | Intronic | NO | No | Novel | 1.37 | 7 |
22 | rs4478545 | 8 | A/G | 94672542 | − 0.01 | 0.002 | 4.77E-09 | 0.285 | LINC00535 | ncRNA_intronic | NO | No | Novel | 1.326 | 6 |
23 | rs3793577 | 9 | A/G | 23737627 | − 0.01 | 0.002 | 3.46E-10 | 0.463 | ELAVL2 | Intronic | NO | Neuroticism | Known | 19.76 | 5 |
24 | rs4744242 | 9 | T/G | 96236711 | − 0.011 | 0.002 | 8.68E-13 | 0.336 | FAM120A | Intronic | YES | Neuroticism | Known | 2.858 | 6 |
25 | rs10123941 | 9 | T/C | 120518162 | − 0.01 | 0.002 | 3.96E-09 | 0.727 | snoZ13_snr52 | Intergenic | NO | Neuroticism | Known | 1.108 | 6 |
26 | rs6584631 | 10 | T/C | 106656137 | − 0.01 | 0.002 | 7.23E-09 | 0.244 | SORCS3 | Intronic | NO | Depression | Known | 0.167 | 4 |
27 | rs4937872 | 11 | A/G | 112827715 | − 0.012 | 0.002 | 7.15E-15 | 0.589 | RP11-629G13.1 | Intergenic | YES | Neuroticism | Known | 0.044 | 6 |
28 | rs9530139 | 13 | T/C | 31847324 | − 0.011 | 0.002 | 2.11E-08 | 0.194 | B3GALTL | Intronic | NO | Depression | Known | 0.529 | 6 |
29 | rs9597797 | 13 | T/G | 59183795 | − 0.01 | 0.002 | 1.42E-09 | 0.251 | CTAGE16P | Intergenic | NO | Neuroticism | Known | 0.278 | 7 |
30 | rs2121708 | 14 | A/G | 42146572 | − 0.009 | 0.001 | 8.26E-10 | 0.517 | LRFN5 | Intronic | NO | Depression | Known | 0.043 | NA |
31 | rs35641442 | 14 | A/G | 75207263 | 0.009 | 0.002 | 6.65E-09 | 0.459 | FCF1 | Intergenic | NO | Neuroticism & depression | Known | 11.4 | 7 |
32 | rs1862743 | 16 | A/C | 60743834 | − 0.009 | 0.001 | 1.08E-08 | 0.492 | GNPATP | Intergenic | NO | No | Novel | 1.06 | 6 |
33 | rs11877758 | 18 | T/G | 35138110 | − .,012 | 0.002 | 1.28E-13 | 0,692 | CELF4 | Intronic | NO | Neuroticism & depression | Known | 2.718 | 7 |
33 | rs2978362 | 18 | T/C | 32959397 | − 0.008 | 0.001 | 2.65E-08 | 0.527 | ZNF396 | Intergenic | NO | Depression | Known | 1.024 | NA |
34 | rs12958048 | 18 | A/G | 53101598 | 0.01 | 0.002 | 4.76E-11 | 0,333 | TCF4 | Intronic | NO | Neuroticism | Known | 2,08 | 5 |
34 | rs17410557 | 18 | T/C | 50776391 | − .,009 | 0.002 | 1.13E-08 | 0,606 | DCC | Intronic | NO | Neuroticism & depression | Known | 4.502 | 7 |
35 | rs2111530 | 19 | A/G | 31891006 | − 0.009 | 0.002 | 9.47E-09 | 0.602 | AC007796.1 | ncRNA_intronic | NO | No | Novel | 17.04 | 7 |
36 | rs2024568 | 20 | T/C | 44732089 | 0.011 | 0.002 | 1.52E-10 | 0.246 | RPL13P2 | Intergenic | NO | Neuroticism & depression | Known | 0.149 | 6 |
37 | rs11090039 | 22 | A/G | 41496800 | 0.012 | 0.002 | 2.87E-13 | 0.284 | EP300 | Intronic | NO | Neuroticism | Known | 9.707 | 5 |