Fig. 1

Behavioral results in sham, anhedonia-susceptible, and anhedonia-resilient mice. A Schedule of the experiment. SNI surgery was performed after acclimation. MWT was measured on days 7, 14, and 21 after SNI. The SPT was performed on days 5, 12, and 19 after SNI. B Dendrogram of the hierarchical clustering analysis. A total of 18 SNI mice were classified into anhedonia-susceptible and anhedonia-resilient groups by a hierarchical cluster analysis of the SPT results. C MWT [Time: F (3, 21) = 124.2, P < 0.001; Group: F (2, 14) = 118, P < 0.001; Interaction: F (6, 42) = 17.12, P < 0.001] was measured on days 7, 14, and 21 in the sham, anhedonia-resilient, and anhedonia-susceptible groups after SNI. ^***P < 0.001, susceptible group vs.. sham group; ^###P < 0.001, resilient group vs.. sham group. D SPT [Time: F (2, 14) = 1.873, P = 0.19; Group: F (2, 14) = 49.95, P < 0.001; Interaction: F (4, 28) = 1.616, P = 0.20] was measured in the sham, anhedonia-resilient, and anhedonia-susceptible groups on days 5, 12, and 19 after SNI. ^***P < 0.001. MWT mechanical withdrawal threshold, SNI spared nerve injury, SPT sucrose preference test