Fig. 1

Patient overview. A total of 451 patients were included in the final analysis, of which 380 were baseline RET+ patients and 71 were EGFR-mutated patients who acquired RET fusions after resistance to EGFR-TKIs. Only baseline RET fusion-positive (RET+) patients with available FFPE and/or biopsy tumor samples were qualified for the following tests. Acquired RET+ patients (N = 71) were those who gained RET fusions after EGFR-TKI treatments targeting primary EGFR oncogenic mutations. Samples belonging to this category were divided into three groups depending on when RET fusion was detected. Specifically, group 1 contains 13 patients treated with first-line (1L) 1st- or 2nd-G EGFR-TKIs. Group 2 includes 51 patients who received second-line (2L) 3rd-G EGFR-TKI treatment. Lastly, group 3 consists of 7 patients previously treated with 1L 3rd-G EGFR-TKIs